Immunological evidence for common antigenic sites in high-density lipoproteins from rainbow trout and man

Abstract

The plasma high-density lipoproteins (HDL, rho 1.085-1.21 g/ml) of rainbow trout (Salmo gairdneri) have been shown to contain large amounts of apolipoprotein (apo) AI (Mr 28,000) and several other apolipoproteins of Mr less than 14,000 (apo C-like) and of Mr 37,000-38,000, 44,000-45,000 and 53,000-54,000. Comparison of apo AI from trout and human HDL shows them to be similar in Mr and to have some cross-immunoreactivity, whereas apo AII differs in Mr but also possesses common antigenic sites. It is suggested that the major apolipoproteins of fish and human HDL may fulfil similar roles in lipid transport.