Completing the folate biosynthesis pathway in Plasmodium falciparum: p-aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase-Reference-Cited by-同舟云学术

Completing the folate biosynthesis pathway in Plasmodium falciparum: p-aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase

Published:2013-09-27 Issue:2 Volume:455 Page:149-155
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Magnani Giovanni¹,Lomazzi Michela²,Peracchi Alessio¹

Affiliation:

1. Department of Life Sciences, Laboratory of Biochemistry, Molecular Biology and Bioinformatics, University of Parma, 43124 Parma, Italy

2. Department of Chemistry, University of Parma, 43124 Parma, Italy

Abstract

Enzymes that produce or recycle folates are the targets of widely used antimalarial drugs. Despite the interest in the folate metabolism of Plasmodium falciparum, the molecular identification of ADCL (aminodeoxychorismate lyase), which synthesizes the p-aminobenzoate moiety of folate, remained unresolved. In the present study, we demonstrate that the plasmodial gene PF14_0557 encodes a functional ADCL and report a characterization of the recombinant enzyme.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/455/2/149/735603/bj4550149.pdf

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