Author:
Knott-Hunziker V,Orlek B S,Sammes P G,Waley S G
Abstract
The inactivation of beta-lactamase I by preparations of 6alpha-bromopenicillanic acid showed unexpected kinetic features that indicated that the active species was the 6beta-epimer. Samples containing 6beta-bromopenicillanic acid have been synthesized and shown to inactivate the enzyme in a rapid stoicheiometric reaction.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
88 articles.
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