Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme-Reference-Cited by-同舟云学术

Hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme

Published:1974-09-01 Issue:3 Volume:141 Page:915-917
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Dorer Frederic E.¹,Ryan James W.²,Stewart John M.³

Affiliation:

1. Hypertension Research Laboratory, Veterans Administration Hospital and Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A.

2. Papanicolaou Cancer Research Institute and Department of Medicine, University of Miami School of Medicine, Miami, Fla. 33152, U.S.A.

3. Department of Biochemistry, University of Colorado School of Medicine, Denver, Colo. 80220, U.S.A.

Abstract

The hydrolysis of bradykinin and its higher homologues by angiotensin-converting enzyme has been investigated by using an automated ninhydrin technique. The results show an inverse relationship of hydrolysis rate with size and charge of the peptide, which parallels the inactivation in the pulmonary circulation and offers an explanation for the selectivity of metabolism of these kinins by the lungs.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/141/3/915/563048/bj1410915.pdf

Cited by 77 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design;Journal of Medicinal Chemistry;2016-10-12

2. Kallikrein in the Interstitial Space;Protein Science;2016-08-04

3. Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment;Annals of Medicine;2016-03-26

4. Prolonged signalling and trafficking of the bradykinin B2 receptor stimulated with the amphibian peptide maximakinin: Insight into the endosomal inactivation of kinins;Pharmacological Research;2012-02

5. Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors?;Kidney International;2009-07