Affiliation:
1. Abteilung Innere Medizin I, University of Ulm, Universitätsklinikum Ulm, Robert-Koch-Strasse 8, 89081 Ulm, Federal Republic of Germany
Abstract
We have cloned and sequenced genomic DNA from a human library extending 1300 bp upstream the 5´-untranslated sequence of the cDNA coding for the sodium/iodide symporter. In transient transfection assays this sequence exhibited promoter activity, which could be confined to nucleotides -443 to -395 relative to the ATG start codon. This minimal promoter, including a putative GC- and TATA- box, was preferentially activated in the rat thyroid cell line FRTL-5, but was also active in non-thyroidal cells, such as COS-7 and Chinese-hamster ovary, albeit to a markedly lower extent.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
52 articles.
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