Do mitochondrial DNA mutations have a role in neurodegenerative disease?-Reference-Cited by-同舟云学术

Do mitochondrial DNA mutations have a role in neurodegenerative disease?

Published:2007-10-25 Issue:5 Volume:35 Page:1232-1235
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Krishnan K.J.¹,Reeve A.K.¹,Turnbull D.M.¹

Affiliation:

1. Mitochondrial Research Group, Neurology, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.

Abstract

A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some of the major evidence surrounding mitochondrial DNA mutations leading to mitochondrial dysfunction in neurodegenerative disease and discuss their possible role in neurodegeneration.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/35/5/1232/549881/bst0351232.pdf

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