Exosomes and extracellular vesicles: the path forward

Author:

Stahl Philip D.1,Raposo Graça23

Affiliation:

1. Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.

2. Institut Curie, PSL Research University, CNRS, UMR 144, F-75005, Paris, France

3. Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 144, F-75005, Paris, France

Abstract

Over the course of the past several decades, the concept that extracellular vesicles, exosomes and microvesicles, operate as cellular “housekeepers” and as agents for communication between and among cells and tissues, has emerged into one of the most promising yet vexing problems facing the biomedical community. Already, extracellular vesicles from biological fluids are being used for diagnostic purposes and hopes abound for their use as therapeutic agents. However, the most basic mechanistic questions surrounding their biogenesis and function in cellular and tissue homeostasis remain largely unexplored. In this issue of Essays in Biochemistry, the rise of a new intercellular communications pathway is considered from many perspectives—cell biology, physiology, and pathophysiology.

Publisher

Portland Press Ltd.

Subject

Molecular Biology,Biochemistry

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