The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner-Reference-Cited by-同舟云学术

The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

Published:2015-03-20 Issue:1 Volume:467 Page:47-62
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Bailey Fiona P.¹,Byrne Dominic P.¹,Oruganty Krishnadev²,Eyers Claire E.¹,Novotny Christopher J.³,Shokat Kevan M.³,Kannan Natarajan²⁴,Eyers Patrick A.¹

Affiliation:

1. Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, U.K.

2. Institute of Bioinformatics, University of Georgia, Athens, GA 30602, U.S.A.

3. Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, UCSF, San Francisco, CA 94158, U.S.A.

4. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, U.S.A.

Abstract

We report that Tribbles 2 (TRB2), a pseudokinase linked to cancer, binds ATP and autophosphorylates in a metal-independent manner. This activity is prevented by mutations in the ATP-binding site and a TRB2 mutant can be targeted with a small molecule ligand.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/1/47/683286/bj4670047.pdf

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