Plasma α2 HS-glycoprotein Concentration in Paget's Disease of Bone: its Possible Significance

Author:

Ashton B. A.1,Smith R.2

Affiliation:

1. MRC Bone Research Laboratory, Oxford, U.K.

2. Nuffield Orthopaedic Centre, Oxford, U.K.

Abstract

1. The plasma concentration of the α2HS-glycoprotein has been measured in 58 normal adults and in patients with Paget's disease of bone before (24) and during treatment (16). 2. The average plasma α2HS-glycoprotein was lower in the patients with Paget's disease than in the normal adults and was inversely related to plasma alkaline phosphatase activity (r = −0.55, n = 24, P<0.001). 3. When the patients with Paget's disease were treated with either diphosphonate or calcitonin, the plasma α2HS-glycoprotein concentration increased towards normal. In those patients treated with calcitonin, this increase was too rapid to be entirely accounted for by a cessation of bone formation.

Publisher

Portland Press Ltd.

Subject

General Medicine

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