Propranolol Block of Adrenaline-Induced Hypophosphataemia in Man

Abstract

1. The effect of propranolol on adrenaline- and insulin-induced hypophosphataemia was studied in man. 2. β-Adrenergic blockade with propranolol almost completely abolished and significantly inhibited adrenaline- and insulin-induced hypophosphataemia respectively; in addition, the drug clearly prevented the normally observed rise in plasma lactate, while causing only a slight change in blood glucose levels. 3. It is suggested that the fall in blood phosphate values induced by adrenaline and, in part, that caused by insulin, is mediated by β-adrenergic receptors.