Response to indomethacin and hydrochlorothiazide in nephrogenic diabetes insipidus

Author:

Monnens L.1,Jonkman A.1,Thomas C.2

Affiliation:

1. Department of Pediatrics, University of Nijmegen, Nijmegen, The Netherlands

2. Department of Obstetrics and Gynaecology, University of Nijmegen, Nijmegen, The Netherlands

Abstract

1. Four boys with classical nephrogenic diabetes insipidus have been treated by indomethacin, by hydrochlorothiazide, and by the combination of indomethacin and hydrochlorothiazide. 2. Hydrochlorothiazide treatment was slightly more effective than indomethacin treatment in reducing the urine volume and increasing the urine osrnolality. 3. The combination of indomethacin and hydrochlorothiazide appeared to be additive and especially helpful in infants and young children before the autonomy of drinking.

Publisher

Portland Press Ltd.

Subject

General Medicine

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