Comparison of the Appearance of Radiolabelled Vitamin D3 and 25-Hydroxy-Vitamin D3 in the Chylomicron Fraction of Plasma after Oral Administration in Man-Reference-Cited by-同舟云学术

Comparison of the Appearance of Radiolabelled Vitamin D3 and 25-Hydroxy-Vitamin D3 in the Chylomicron Fraction of Plasma after Oral Administration in Man

Published:1981-02-01 Issue:2 Volume:60 Page:241-243
ISSN:0143-5221
Container-title:Clinical Science
language:en
Short-container-title:

Author:

Compston Juliet E.¹,Merrett Anne L.¹,Hammett F. G.¹,Magill P.¹

Affiliation:

1. Gastrointestinal Research Unit, Rayne Institute, and Department of Chemical Pathology and Metabolic Disorders, St Thomas' Hospital, London

Abstract

1. The uptake of either orally administered [3H]vitamin D3 or 25-[3H]hydroxy-vitamin D3 into the chylomicron fraction of plasma was studied in 12 healthy male subjects. 2. The amount of [3H]vitamin D3 in the chylomicron fraction expressed as a percentage of the total plasma radioactivity was higher than that of 25-[3H]hydroxy-vitamin D3. 3. It is suggested that the mechanism of intestinal absorption of vitamin D and 25-hydroxy-vitamin D may differ in man, the absorption of 25-hydroxy-vitamin D possibly being less dependent on bile acids.

Publisher

Portland Press Ltd.

Subject

General Medicine

Link

https://portlandpress.com/clinsci/article-pdf/60/2/241/452839/cs0600241.pdf

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