Rag proteins regulate amino-acid-induced mTORC1 signalling-Reference-Cited by-同舟云学术

Rag proteins regulate amino-acid-induced mTORC1 signalling

Published:2009-01-20 Issue:1 Volume:37 Page:289-290
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Sancak Yasemin¹²,Sabatini David M.¹²³

Affiliation:

1. Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology Department of Biology, Nine Cambridge Center, Cambridge, MA 02142, U.S.A.

2. MIT Center for Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, U.S.A.

3. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, U.S.A.

Abstract

The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPase) family of GTPases as mediators of amino acid signalling to mTOR is an important step towards our understanding of this mechanism.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/37/1/289/545975/bst0370289.pdf

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