Relationship between Plasma High-Density Lipoprotein Concentrations and Lipoprotein Lipase and Hepatic Lipase Activities in Children with Hyperlipidaemia

Abstract

1. Significant positive correlations were found between the lipoprotein lipase and hepatic lipase activities of post-heparin plasma samples and plasma high-density-lipoprotein (HDL) cholesterol concentrations in 21 children with hyperlipidaemia and six normal adult males. 2. A significant positive correlation was also observed between the two lipase activities and the ratio of HDL cholesterol to apoprotein AI (apo AI) concentrations. 3. These findings provide further evidence that a significant proportion of HDL and possibly the HDL2 subfraction is formed during the clearance of triglyceride-rich lipoproteins.