Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase

Author:

Blayney L M1,Gapper P W1,Newby A C1

Affiliation:

1. Department of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K.

Abstract

We have further characterized a putative receptor-operated Ca2+ channel that is activated by histamine and guanosine 5′-[beta gamma-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMP-dependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

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