Co-operative transport by molecular motors

Author:

Berger Florian1,Keller Corina1,Müller Melanie J.I.2,Klumpp Stefan1,Lipowsky Reinhard1

Affiliation:

1. Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany

2. Physics Department, Harvard University, Cambridge, MA 02138, U.S.A.

Abstract

Intracellular transport is often driven co-operatively by several molecular motors, which may belong to one or several motor species. Understanding how these motors interact and what co-ordinates and regulates their movements is a central problem in studies of intracellular transport. A general theoretical framework for the analysis of such transport processes is described, which enables us to explain the behaviour of intracellular cargos by the transport properties of individual motors and their interactions. We review recent advances in the theoretical description of motor co-operativity and discuss related experimental results.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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