Insulin release from the perfused rat pancreas. Mode of action of tolbutamide-Reference-Cited by-同舟云学术

Insulin release from the perfused rat pancreas. Mode of action of tolbutamide

Published:1974-08-15 Issue:2 Volume:142 Page:385-389
ISSN:0306-3283
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Bowen Vyvyan¹,Lazarus Norman R.¹

Affiliation:

1. Diabetes Research Unit, The Wellcome Foundation Limited, Temple Hill, Dartford, Kent DA1 5AH, U.K.

Abstract

Dextran-linked tolbutamide causes first-phase insulin release when perfused through the isolated rat pancreas. The linked sulphonylurea is also able to stimulate the membranal adenylate cyclase present in mouse islets. These facts make it highly likely that sulphonylureas exert their pharmacological action by interaction with the plasma membrane. Their action may be mediated via the adenylate cyclase enzyme.

Publisher

Portland Press Ltd.

Link

https://portlandpress.com/biochemj/article-pdf/142/2/385/781261/bj1420385.pdf

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