Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology-Reference-Cited by-同舟云学术

Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology

Published:2021-07-23 Issue:5 Volume:5 Page:691-697
ISSN:2397-8554
Container-title:Emerging Topics in Life Sciences
language:en
Short-container-title:

Author:

Epple Sven¹^ORCID,El-Sagheer Afaf H.¹²^ORCID,Brown Tom¹^ORCID

Affiliation:

1. Chemistry Research Laboratory, University of Oxford, Oxford OX1 3TA, U.K.

2. Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt

Abstract

The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.

Publisher

Portland Press Ltd.

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://portlandpress.com/emergtoplifesci/article-pdf/5/5/691/924328/etls-2021-0169c.pdf

Reference71 articles.

1. The chemical evolution of oligonucleotide therapies of clinical utility;Nat. Biotechnol.,2017

2. The medicinal chemistry of therapeutic oligonucleotides;J. Med. Chem.,2016

3. Phosphonomethyl oligonucleotides as backbone-modified artificial genetic polymers;J. Am. Chem. Soc.,2018

4. A synthetic genetic polymer with an uncharged backbone chemistry based on alkyl phosphonate nucleic acids;Nat. Chem.,2019

5. Reprint of: non canonical genetic material;Curr. Opin. Biotechnol.,2019

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