Affiliation:
1. M.R.C. Group in Iron and Porphyrin Metabolism, Gardiner Institute, Western Infirmary, Glasgow
Abstract
1.β-Aminolaevulic acid (ALA) dehydrase activity has been measured in the blood of man and rats and in the tissues of rats intoxicated with ethanol.
2. ALA dehydrase activity was significantly depressed in the blood of man. This depression follows closely on the elevation of blood ethanol and returns to normal pari passu with the ethanol level.
3. In rats intoxicated with ethanol there is a significant depression of ALA dehydrase activity in blood, liver and kidney but not in heart or spleen.
4. A scheme is proposed whereby an increase in the intracellular redox potential by ethanol increases sulphydryl cofactor concentrations leading to an inhibition of enzyme activity.
Cited by
119 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献