The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4-Reference-Cited by-同舟云学术

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

Published:2009-03-13 Issue:1 Volume:419 Page:57-63
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Plant Pamela J.¹,Correa Judy¹,Goldenberg Neil¹,Bain James²,Batt Jane¹³

Affiliation:

1. Department of Medicine, Clinical Sciences Division, Room 7344, Medical Science Building, University of Toronto, Toronto, 1 Kings College Circle, Ontario, Canada, M5S 1A8

2. Department of Surgery, MacMaster University Hospital, 1200 Main St. West, Hamilton, Ontario, Canada, L8N 3Z5

3. Department of Medicine, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada, M5B 1W8

Abstract

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-localized to late endosomes. The PY (Pro-Tyr) motif of hMTMR4 binds to WW (Trp-Trp) domains of hNedd4. MTMR4 expression was decreased in atrophying muscle, whereas Nedd4 expression was increased and hMTMR4 was ubiquitinated by hNedd4, suggesting that this novel interaction may underlie the biological process of muscle breakdown.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/419/1/57/657900/bj4190057.pdf

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