Affiliation:
1. Worcester Foundation for Experimental Biology, Shrewsbury, Mass. 01545, U.S.A.
Abstract
Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure–activity relationships were ascertained.
Cited by
19 articles.
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