Affiliation:
1. Department of Surgery, Division of Cardiothoracic Surgery, The Carlyle Fraser Heart Center, Emory University School of Medicine, Atlanta, GA 30308, U.S.A.
Abstract
H2S (hydrogen sulfide), viewed with dread for more than 300 years, is rapidly becoming a ubiquitously present and physiologically relevant signalling molecule. Knowledge of the production and metabolism of H2S has spurred interest in delineating its functions both in physiology and pathophysiology of disease. Although its role in blood pressure regulation and interaction with NO is controversial, H2S, through its anti-apoptotic, anti-inflammatory and antioxidant effects, has demonstrated significant cardioprotection. As a result, a number of sulfide-donor drugs, including garlic-derived polysulfides, are currently being designed and investigated for the treatment of cardiovascular conditions, specifically myocardial ischaemic disease. However, huge gaps remain in our knowledge about this gasotransmitter. Only by additional studies will we understand more about the role of this intriguing molecule in the treatment of cardiovascular disease.
Reference151 articles.
1. Massive release of hydrogen sulfide to the surface ocean and atmosphere during intervals of oceanic anoxia;Kump;Geology,2005
2. If almost every species on Earth was killed some 250 million years ago, how did our ancient ancestors survive and evolve into us?;Ward,2008
3. Hydrogen sulfide may kill us, bring us back to life;Zetter,2008
4. The Development of Life on Earth;Townsend,2009
5. Evolution and biogeography of deep-sea vent and seep invertebrates;Van Dover;Science,2002
Cited by
127 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献