Association of Secondary Hyperparathyroidism with Red Cell Survival in Chronic Haemodialysis Patients

Abstract

1. 51Cr red cell mass (RCM), 51Cr red cell survival (RCS) and plasma parathyroid hormone (PTH) levels were measured in 27 stable chronic haemodialysis patients with a variable degree of clinical secondary hyperparathyroidism. Included were five patients who had had total parathyroidectomy. 2. The results showed a strong negative correlation between PTH and RCS (r = −0.67, P<0.001) and a positive correlation between RCS and RCM (r = + 0.53, P<0.005). However, the negative correlation between PTH and RCM was weak (r = −0.45, P<0.02). When the 13 patients with normal PTH levels (mean 0.18 ± 0.12 μg/l) were compared with the 14 patients with raised levels (mean 1.35 ± 0.71 μg/l), there was a marked difference in RCS (P<0.005) but no difference in RCM.