Modelling the effects of inhibitors of guanine nucleotide synthesis: implications for studies of cellular differentiation pathways-Reference-Cited by-同舟云学术

Modelling the effects of inhibitors of guanine nucleotide synthesis: implications for studies of cellular differentiation pathways

Published:2010-09-24 Issue:5 Volume:38 Page:1314-1318
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Thomas Geraint M.H.¹

Affiliation:

1. Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K., Department of Structural & Molecular Biology, University College London, Gower Street, London, WC1E 6BT, U.K., and CoMPLEX, University College London, Gower Street, London WC1E 6BT, U.K.

Abstract

Mizoribine induces the differentiation of promyelocytes by an unknown mechanism that relies on compromised guanine nucleotide synthesis. I have found that mizoribine also perturbs adenosine nucleotide levels in HL-60 promyelocytes, particularly ATP. To reconcile these observations with the known actions of mizoribine I have adapted an existing model of human purine metabolism composed as an S-system familiar from Biochemical Systems Theory. Mizoribine's actions were then simulated and compared with experimental data.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/38/5/1314/547433/bst0381314.pdf

Reference14 articles.

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