Being in a loop: how long non-coding RNAs organise genome architecture

Author:

Pisignano Giuseppina1ORCID,Pavlaki Ioanna1,Murrell Adele1ORCID

Affiliation:

1. Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Abstract

Abstract Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat. Genet. (2002) 30, 329–334]. Long non-coding RNAs (lncRNAs) are able to control chromatin structure through nucleosome positioning, interaction with chromatin re-modellers and chromosome looping. These functions are carried out in cis at the site of lncRNAs transcription or in trans at distant loci. While the evidence for a role in lncRNAs in regulating gene expression through chromatin interactions is increasing, there is still very little conclusive evidence for a potential role in looping organisation. Here, we review models for the involvement of lncRNAs in genome architecture and the experimental evidence to support them.

Publisher

Portland Press Ltd.

Subject

Molecular Biology,Biochemistry

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