Amylin receptors: molecular composition and pharmacology-Reference-Cited by-同舟云学术

Amylin receptors: molecular composition and pharmacology

Published:2004-10-26 Issue:5 Volume:32 Page:865-867
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Hay D.L.¹,Christopoulos G.²,Christopoulos A.³,Sexton P.M.²³

Affiliation:

1. School of Biological Sciences, University of Auckland, Symonds Street, Auckland, New Zealand

2. Howard Florey Institute, The University of Melbourne, Victoria 3010, Australia

3. Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia

Abstract

Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin) receptor at its core, plus a RAMP (receptor activity modifying protein). The receptors have been named AMY1(a), AMY2(a) and AMY3(a) in accordance with the association of the CT receptor (CT(a)) with RAMP1, RAMP2 and RAMP3 respectively. The challenge is now to determine the localization and pharmacological nature of each of these receptors. Recent attempts to achieve these aims will be briefly discussed.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/32/5/865/537253/bst0320865.pdf

Reference15 articles.

1. International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors

2. Amylin Compared with Calcitonin Gene-Related Peptide: Structure, Biology, and Relevance to Metabolic Disease

3. Characterization of Amylin and Calcitonin Receptor Binding in the Mouse α-Thyroid-Stimulating Hormone Thyrotroph Cell Line*

4. Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product

5. Receptor activity modifying proteins

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