Mechanism of action of nucleotide excision repair machinery-Reference-Cited by-同舟云学术

Mechanism of action of nucleotide excision repair machinery

Published:2022-01-25 Issue:1 Volume:50 Page:375-386
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

D'Souza Areetha¹,Blee Alexandra M.¹,Chazin Walter J.¹^ORCID

Affiliation:

1. Departments of Biochemistry and Chemistry, Center for Structural Biology, Vanderbilt University, Nashville, TN 37240-7917, U.S.A.

Abstract

Nucleotide excision repair (NER) is a versatile DNA repair pathway essential for the removal of a broad spectrum of structurally diverse DNA lesions arising from a variety of sources, including UV irradiation and environmental toxins. Although the core factors and basic stages involved in NER have been identified, the mechanisms of the NER machinery are not well understood. This review summarizes our current understanding of the mechanisms and order of assembly in the core global genome (GG-NER) pathway.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/50/1/375/930233/bst-2021-0246c.pdf

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