A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps-Reference-Cited by-同舟云学术

A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps

Published:2012-07-27 Issue:1 Volume:446 Page:159-163
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Branitzki-Heinemann Katja¹,Okumura Cheryl Y.¹,Völlger Lena²,Kawakami Yuko³,Kawakami Toshiaki³,Naim Hassan Y.²,Nizet Victor¹⁴,Von Köckritz-Blickwede Maren²

Affiliation:

1. Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, U.S.A.

2. Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Buenteweg 17, 30559 Hannover, Germany

3. Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, U.S.A.

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, U.S.A.

Abstract

MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/446/1/159/671368/bj4460159.pdf

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