NUAK: never underestimate a kinase-Reference-Cited by-同舟云学术

NUAK: never underestimate a kinase

Published:2024-06-28 Issue: Volume: Page:
ISSN:0071-1365
Container-title:Essays in Biochemistry
language:en
Short-container-title:

Author:

Skalka George L.¹²,Whyte Declan²,Lubawska Dominika¹,Murphy Daniel J.¹²^ORCID

Affiliation:

1. 1School of Cancer Sciences, University of Glasgow, Glasgow, U.K.

2. 2CRUK Scotland Institute, Garscube Estate, Glasgow G61 1BD, U.K.

Abstract

Abstract NUAK1 and NUAK2 belong to a family of kinases related to the catalytic α-subunits of the AMP-activated protein kinase (AMPK) complexes. Despite canonical activation by the tumour suppressor kinase LKB1, both NUAKs exhibit a spectrum of activities that favour tumour development and progression. Here, we review similarities in structure and function of the NUAKs, their regulation at gene, transcript and protein level, and discuss their phosphorylation of specific downstream targets in the context of the signal transduction pathways and biological activities regulated by each or both NUAKs.

Funder

Asthma + Lung UK

Cancer Research UK

Medical Research Council

Publisher

Portland Press Ltd.

Link

https://portlandpress.com/essaysbiochem/article-pdf/doi/10.1042/EBC20240005/958714/ebc-2024-0005c.pdf

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