Systems biology of antioxidants-Reference-Cited by-同舟云学术

Systems biology of antioxidants

Published:2012-04-12 Issue:3 Volume:123 Page:173-192
ISSN:0143-5221
Container-title:Clinical Science
language:en
Short-container-title:

Author:

Andriantsitohaina Ramaroson¹,Duluc Lucie¹,García-Rodríguez Julio C.²,Gil-del Valle Lizette³,Guevara-Garcia Mariela⁴,Simard Gilles¹,Soleti Raffaella¹,Su Ding-Feng⁵,Velásquez-Pérez Luis⁶,Wilson John X.⁷,Laher Ismail⁸

Affiliation:

1. INSERM U1063, Stress Oxydant et Pathologies Métaboliques, Rues des Capucins, 49100 Angers, France

2. National Center for Animal Breeding (CENPALAB), Havana, Cuba

3. Clinical Pharmacology, Institute ‘Pedro Kourí’, Havana, Cuba

4. Biopharmaceutical Laboratories (LABIOFAM), Research and Development Department, Boyeros, Havana, Cuba

5. Department of Pharmacology, Second Military Medical University, Shanghai 200433, China

6. Center for the Research and Rehabilitation of Hereditary Ataxias ‘Carlos J. Finlay’ (CIRAH) Holguín, University of Havana, Carretera Central (Vía Habana), Reparto Edecio Pérez, 80100 Holguín, Cuba

7. Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214-8028, USA

8. †Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada, V6T 1Z4

Abstract

Understanding the role of oxidative injury will allow for therapy with agents that scavenge ROS (reactive oxygen species) and antioxidants in the management of several diseases related to free radical damage. The majority of free radicals are generated by mitochondria as a consequence of the mitochondrial cycle, whereas free radical accumulation is limited by the action of a variety of antioxidant processes that reside in every cell. In the present review, we provide an overview of the mitochondrial generation of ROS and discuss the role of ROS in the regulation of endothelial and adipocyte function. Moreover, we also discuss recent findings on the role of ROS in sepsis, cerebral ataxia and stroke. These results provide avenues for the therapeutic potential of antioxidants in a variety of diseases.

Publisher

Portland Press Ltd.

Subject

General Medicine

Link

https://portlandpress.com/clinsci/article-pdf/123/3/173/443146/cs1230173.pdf

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