Biochemical effects of diquat and paraquat. Disturbance of the control of corticosteroid synthesis in rat adrenal and subsequent effects on the control of liver glycogen utilization

Abstract

1. Administration of diquat (NN′-ethylene-2,2′-bipyridilium) or paraquat (NN′-dimethyl-4,4′-bipyridilium) prevents the normal depletion of liver glycogen in starved rats. 2. There is an increase in blood glucose, which returns to normal values after approx. 7h. 3. After administration of diquat or paraquat, plasma corticosteroids increase to very high concentrations and remain high for at least 24h, but plasma ACTH (adrenocorticotrophin) is only increased for 4h. 4. Adrenal cyclic AMP is considerably increased after administration of diquat and remains significantly higher than control values for at least 24h. 5. It is suggested that diquat and paraquat increase the response of the adrenal cortex to ACTH.