Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation-Reference-Cited by-同舟云学术

Mammalian gastrulation: signalling activity and transcriptional regulation of cell lineage differentiation and germ layer formation

Published:2022-11-18 Issue:6 Volume:50 Page:1619-1631
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Salehin Nazmus¹²^ORCID,Knowles Hilary¹^ORCID,Masamsetti V. Pragathi¹²^ORCID,Tam Patrick P.L.¹²^ORCID

Affiliation:

1. 1Embryology Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia

2. 2School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia

Abstract

The interplay of signalling input and downstream transcriptional activity is the key molecular attribute driving the differentiation of germ layer tissue and the specification of cell lineages within each germ layer during gastrulation. This review delves into the current understanding of signalling and transcriptional control of lineage development in the germ layers of mouse embryo and non-human primate embryos during gastrulation and highlights the inter-species conservation and divergence of the cellular and molecular mechanisms of germ layer development in the human embryo.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/50/6/1619/941050/bst-2022-0256c.pdf

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