Dissecting structural and electronic effects in inducible nitric oxide synthase-Reference-Cited by-同舟云学术

Dissecting structural and electronic effects in inducible nitric oxide synthase

Published:2015-03-20 Issue:1 Volume:467 Page:153-165
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Hannibal Luciana¹²,Page Richard C.³⁴,Haque Mohammad Mahfuzul¹,Bolisetty Karthik¹,Yu Zhihao¹,Misra Saurav³,Stuehr Dennis J.¹

Affiliation:

1. Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A.

2. Lehrstuhl für Bioanorganische Chemie, Department Chemie und Pharmazie, Universität Erlangen-Nürnberg, Egerlandstraße 1, D-91058, Erlangen, Germany

3. Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A.

4. Department of Chemistry and Biochemistry, Miami University, 651 E. High Street, Oxford, OH 45056, U.S.A.

Abstract

Wild-type inducible NOS oxygenase and mutant W188H were substituted with the electron-rich analogue mesohaem. The absence of structural changes upon mesohaem replacement and the decrease in the enzyme's midpoint potential permitted the dissection of electronic and structural effects.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/1/153/683494/bj4670153.pdf

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