Key functions for gap junctions in skin and hearing-Reference-Cited by-同舟云学术

Key functions for gap junctions in skin and hearing

Published:2011-08-12 Issue:2 Volume:438 Page:245-254
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Scott Claire A.¹,Kelsell David P.¹

Affiliation:

1. Centre for Cutaneous Research, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.

Abstract

Cx (connexin) proteins are components of gap junctions which are aqueous pores that allow intercellular exchange of ions and small molecules. Mutations in Cx genes are linked to a range of human disorders. In the present review we discuss mutations in β-Cx genes encoding Cx26, Cx30, Cx30.3 and Cx31 which lead to skin disease and deafness. Functional studies with Cx proteins have given insights into disease-associated mechanisms and non-gap junctional roles for Cx proteins.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/438/2/245/668009/bj4380245.pdf

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