Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax-Reference-Cited by-同舟云学术

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax

Published:2015-04-17 Issue:3 Volume:467 Page:495-505
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Shamas-Din Aisha¹,Bindner Scott¹,Chi Xiaoke²,Leber Brian¹³,Andrews David W.¹⁴,Fradin Cécile¹⁵

Affiliation:

1. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada

2. Department of Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1, Canada

3. Department of Medicine, McMaster University, Hamilton, Ontario L8S 4K1, Canada

4. Sunnybrook Research Institute and Department of Biochemistry, University of Toronto, Toronto, Ontario M4N 3M5, Canada

5. Department of Physics and Astronomy, McMaster University, Hamilton, Ontario L8S 4M1, Canada

Abstract

tBid (truncated Bid/p15) and Bim activate Bax to permeabilize mitochondria and induce apoptosis. Binding of tBid and Bim to membranes is facilitated by electrostatic interactions. Additionally, cardiolipin (CL), like Mtch2, promotes the activating conformational change of tBid.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/3/495/682087/bj4670495.pdf

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