Regulation of IGFBP-2 expression during fasting-Reference-Cited by-同舟云学术

Regulation of IGFBP-2 expression during fasting

Published:2015-04-17 Issue:3 Volume:467 Page:453-460
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Kang Hye Suk¹,Kim Mi-Young²,Kim Seung-Jae¹,Lee Jae-Ho¹,Kim Yong-Deuk¹,Seo Young-Kyo³,Bae Jae-Hoon¹,Oh Goo-Taeg⁴,Song Dae-Kyu¹,Ahn Yong-Ho²,Im Seung-Soon¹

Affiliation:

1. Department of Physiology, Keimyung University School of Medicine, Daegu 704-701, Republic of Korea

2. Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea

3. School of Life Sciences, UNIST, Ulsan 689-798, Republic of Korea

4. Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea

Abstract

Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2) is known to attenuate the biological action of IGF-1, but its regulatory mechanism remains unclear. We demonstrate the transcriptional regulation of the hepatic Igfbp-2 gene by peroxisome-proliferator-activated receptor (PPAR) α during fasting. We also show how PPARα controls IGF-1 signalling through IGFBP-2.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/3/453/681803/bj4670453.pdf

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