Iron chelation as a potential therapy for neurodegenerative disease-Reference-Cited by-同舟云学术

Iron chelation as a potential therapy for neurodegenerative disease

Published:2008-11-19 Issue:6 Volume:36 Page:1304-1308
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Hider Robert C.¹,Ma Yongmin¹,Molina-Holgado Francisco²,Gaeta Alessandra¹,Roy Sourav¹

Affiliation:

1. Division of Pharmaceutical Sciences, King's College London, Franklin–Wilkins Building, 150 Stamford Street, London SE1 8WA, U.K.

2. Wolfson Centre for Age Related Diseases, The Wolfson Wing, Hodgkin Building, Guy's Campus, London SE1 1UL, U.K.

Abstract

Neurodegenerative disorders include a variety of pathological conditions, which share similar critical metabolic processes such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. Chelation therapy could provide a valuable therapeutic approach to such disease states, since metals, particularly iron, are realistic pharmacological targets for the rational design of new therapeutic agents.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/36/6/1304/852774/bst0361304.pdf

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