The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptophan pyrrolase and their resemblance to those of ethanol-Reference-Cited by-同舟云学术

The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptophan pyrrolase and their resemblance to those of ethanol

Published:1973-11-01 Issue:3 Volume:135 Page:555-557
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Badawy Abdulla A.-B.¹,Evans Myrddin¹

Affiliation:

1. Addiction Unit Research Laboratory, Whitchurch Hospital, Cardiff CF4 7XB, U.K.

Abstract

Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/135/3/555/561563/bj1350555.pdf

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