Central Neurohormonal Mechanisms in Spontaneously Hypertensive Rats Compared with Human Essential Hypertension

Abstract

Consideration of the results obtained in studies of spontaneously hypertensive rats indicates that these animals can serve as useful models for perhaps the most common type of essential hypertension of man. Other variants of essential hypertension probably occur where the relative balance between the genetic elements predisposing to high blood pressure may be somewhat different.