Affiliation:
1. Department of Pharmacology, University of Edinburgh, Edinburgh, Scotland, U.K.
Abstract
1. Hypertension produced in two-kidney Goldblatt dogs was accompanied by a transient fluid retention, reaching a maximum 4 days after clamping.
2. Prostaglandin E and F concentrations in venous blood from the intact kidney also rose transiently, showing a maximum by the fifth day.
3. The rise in prostaglandin release from the intact kidney may be related to the fluid retention.
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