The separation and purification of rat liver UDP-glucuronyltransferase activities towards testosterone and oestrone-Reference-Cited by-同舟云学术

The separation and purification of rat liver UDP-glucuronyltransferase activities towards testosterone and oestrone

Published:1980-08-01 Issue:2 Volume:189 Page:377-380
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Weatherill P J,Burchell B

Abstract

1. Reconstitution of UDP-glucuronyltransferase preparations with phosphataidylcholine liposomes facilitated the purification of testosterone UDP-glucuronyltransferase. 2. Transferase activity towards testosterone co-purifies with that towards 4-nitrophenol. 3. UDP-glucuronyltransferase activity towards oestrone was separated from that towards testosterone. 4. These results suggest that testosterone and 4-nitrophenol may be glucuronidated by a different form of UDP-glucuronyltransferase from the one glucuronidating oestrone.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/189/2/377/573984/bj1890377.pdf

Cited by 50 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep;Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology;2011-06

2. Sterol Glycosyltransferases—The Enzymes That Modify Sterols;Applied Biochemistry and Biotechnology;2011-04-06

3. Takashi Iyanagi: UGT1 gene complex: from Gunn rat to human;Drug Metabolism Reviews;2009-10-21

4. Purification and characterization of a novel glucosyltransferase specific to 27β-hydroxy steroidal lactones from Withania somnifera and its role in stress responses;Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics;2007-09

5. Molecular Mechanism of Phase I and Phase II Drug‐Metabolizing Enzymes: Implications for Detoxification;International Review of Cytology;2007