Affiliation:
1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov St., 32, Moscow 119991, Russia
Abstract
The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu2+ ions, as well as novel N1- and N12-Ac-SpmTriens and bis-Et-SpmTrien (N1,N12-diethyl-1,12-diamino-3,6,9-triazadodecane) are described. Possible applications of SpmTrien and its derivatives to the investigation of the enzymes of polyamine metabolism and spermine cellular functions, including interaction with DNA, are discussed.
Cited by
6 articles.
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1. Antibacterial and Antitumoral Activities of the Spider Acylpolyamine Mygalin Silver Nanoparticles;BioNanoScience;2020-04-17
2. Tautomeric populations of the charged species of 1,12-diamino-3,6,9-triazadodecane (SpmTrien) studied with computer simulations and cluster expansions;Journal of Physical Organic Chemistry;2013-02-26
3. Metabolism of Triethylenetetramine and 1,12-Diamino-3,6,9-Triazadodecane by the Spermidine/Spermine-N1-Acetyltransferase and Thialysine Acetyltransferase;Drug Metabolism and Disposition;2012-09-28
4. Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues;Journal of Medicinal Chemistry;2010-07-20
5. Novel isosteric charge-deficient spermine analogue—1,12-diamino-3,6,9-triazadodecane: synthesis, pK a measurement and biological activity;Amino Acids;2009-12-02