Tuning T helper cell differentiation by ITK-Reference-Cited by-同舟云学术

Tuning T helper cell differentiation by ITK

Published:2020-02-12 Issue:1 Volume:48 Page:179-185
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Elmore Jessica P.¹,McGee Michael C.²,Nidetz Natalie F.²,Anannya Orchi¹,Huang Weishan¹²,August Avery¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, U.S.A

2. Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, U.S.A

Abstract

CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of TH17, Foxp3+ T regulatory (Treg) cells, and Type 1 regulatory T (Tr1) cells, supporting a model of ITK signals controlling a decision point in the effector T cell differentiation process.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/48/1/179/868610/bst-2019-0486c.pdf

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