Affiliation:
1. Department of Human Morphology, Nottingham University Medical School, Nottingham
Abstract
1. Isolation of a self-emptying sac of rat small intestine in vivo halved the cell production rate in the crypts of Lieberkühn as measured by colchicine blockade.
2. Starvation for 48 h of rats with isolated intestinal sacs caused a further halving of cell production rate in the sac.
3. Infusion of distilled water into isolated intestinal sacs for 72 h caused a similar degree of stimulation of cell production in sacs in fed and starved rats, suggesting that the fall in cell production rate on starving a rat bearing an isolated sac is not due to the non-availability of the substances required for cell synthesis.
4. The possible contribution of innervation of the gut, and of systemic hormonal influences, on intestinal epithelial replacement is discussed.
Cited by
28 articles.
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