Investigations on metabolites of vitamin D in rat bile. Separation and partial identification of a major metabolite

Author:

Bell P. A.1,Kodicek E.1

Affiliation:

1. Dunn Nutritional Laboratory, University of Cambridge and Medical Research Council, Cambridge

Abstract

1. Young rats with cannulated bile ducts were given 0·34mg. of [1α−3H]cholecalciferol or 0·54mg. of [14C]ergocalciferol by intravenous infusion. Of the radioactivity in the dose of [1α−3H]cholecalciferol 31% was recovered in bile within 24hr. 2. The metabolites in bile were separated by gradient-elution column chromatography on silicic acid into five components, all more polar than cholecalciferol or 25-hydroxycholecalciferol. [14C]Ergocalciferol gave a similar pattern of metabolites in bile. 3. The three most polar metabolites were shown to be ionic. The major component has been identified as a glucuronide conjugate, which was not identical with synthetic cholecalciferyl glucuronide.

Publisher

Portland Press Ltd.

Cited by 56 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. There is more to life than serum vitamin D: a lesson from the past;Clinical Science;2022-04

2. Vitamin D toxicity related to its physiological and unphysiological supply;Trends in Endocrinology & Metabolism;2021-11

3. The Role of Skeletal Muscle in Maintaining Vitamin D Status in Winter;Current Developments in Nutrition;2019-07-25

4. Evolutionary Biology;Vitamin D;2018

5. Calcitroic Acid–A Review;ACS Chemical Biology;2016-09-06

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3