The role of palmitoylation in regulating Ras localization and function-Reference-Cited by-同舟云学术

The role of palmitoylation in regulating Ras localization and function

Published:2013-01-29 Issue:1 Volume:41 Page:79-83
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Eisenberg Sharon¹,Laude Alex J.²,Beckett Alison J.²,Mageean Craig J.²,Aran Veronica²,Hernandez-Valladares Maria²,Henis Yoav I.¹,Prior Ian A.²

Affiliation:

1. Department of Neurobiology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

2. Division of Physiology, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, U.K.

Abstract

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/41/1/79/487249/bst0410079.pdf

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