Phenylalanine metabolism in isolated rat liver cells. Effects of glucagon and diabetes

Author:

Carr F P A,Pogson C I

Abstract

1. Methods are described for monitoring the metabolic flux through phenylalanine hydroxylase, the tyrosine catabolic pathway and phenylalanine: pyruvate transaminase in isolated liver cell incubations. 2. The relationship between hydroxylase flux and phenylalanine concentration is sigmoidal. 3. Glucagon increases hydroxylase activity at low, near-physiological, substrate concentrations only. The hormone does not affect the rate of formation of phenylpyruvate. 4. Experimental diabetes (for 10 days) increases phenylalanine catabolism, and this is further increased by glucagon. 5. These results are discussed in the light of the known mechanisms for control of phenylalanine hydroxylase activity in vitro.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Cited by 41 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Effect of liver cirrhosis on phenylalanine and tyrosine metabolism;Current Opinion in Clinical Nutrition and Metabolic Care;2010-01

2. Phenylalanine and tyrosine kinetics in compensated liver cirrhosis: effects of meal ingestion;American Journal of Physiology-Gastrointestinal and Liver Physiology;2008-09

3. The Phenylalanine Hydroxylating System;Advances in Enzymology - and Related Areas of Molecular Biology;2006-11-22

4. Postprandial body protein synthesis and amino acid catabolism measured with leucine and phenylalanine-tyrosine tracers;American Journal of Physiology-Endocrinology and Metabolism;2003-05-01

5. Hyperglucagonemia in Rats Results in Decreased Plasma Homocysteine and Increased Flux through the Transsulfuration Pathway in Liver;Journal of Biological Chemistry;2001-11

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