Affiliation:
1. The State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China
Abstract
TGF-β (transforming growth factor-β) is a pleiotropic cytokine regulating diverse cellular processes. It signals through membrane-bound receptors, downstream Smad proteins and/or other signalling mediators. Smad7 has been well established to be a key negative regulator of TGF-β signalling. It antagonizes TGF-β signalling through multiple mechanisms in the cytoplasm and in the nucleus. Smad7 can be transcriptionally induced by TGF-β and other growth factors and serves as an important cross-talk mediator of the TGF-β signalling pathway with other signalling pathways. Accordingly, it plays pivotal roles in embryonic development and adult homoeostasis, and altered expression of Smad7 is often associated with human diseases, such as cancer, tissue fibrosis and inflammatory diseases.
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference142 articles.
1. Specificity and versatility in TGF-β signaling through Smads;Feng;Annu. Rev. Cell Dev. Biol.,2005
2. Mechanisms of TGF-β signaling from cell membrane to the nucleus;Shi;Cell,2003
3. Smad7: a new key player in TGF-β-associated disease;Nakao;Trends Mol. Med.,2002
4. Fine tuning and cross-talking of TGF-β signal by inhibitory Smads;Park;J. Biochem. Mol. Biol.,2005
5. Regulation of TGF-β signaling by Smad7;Yan;Acta Biochim. Biophys. Sin.,2009
Cited by
180 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献