Formation of angiotensin III by angiotensin-converting enzyme-Reference-Cited by-同舟云学术

Formation of angiotensin III by angiotensin-converting enzyme

Published:1976-04-01 Issue:1 Volume:155 Page:189-192
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Chiu A T¹,Ryan J W¹,Stewart J M²,Dorer F E³

Affiliation:

1. Papanicolaou Cancer Research Institute and Department of Medicine, University of Miami, FL 33136, U.S.A.

2. Department of Biochemistry, University of Colorado Medical Center, Denver, CO 80220, U.S.A.

3. Hypertension Research Laboratory, Veterans Administration Hospitaland Department of Biochemistry, Case Western Reserve University, Cleveland, OH44106, U.S.A.

Abstract

Angiotensin III is formed from des-Asp1 -angiotensin I by angiotensin-converting enzyme. The Km (11 muM) of the reaction is one-third of that for the conversion of angiotensin I into angiotensin II. As suggested by the Km values, bradykinin, peptide BPP9a and angiotensins II and III are better inhibitors of the formation of angiotensin II than of the formation of angiotensin III.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/155/1/189/566170/bj1550189.pdf

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