Dehydrogenation of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase-Reference-Cited by-同舟云学术

Dehydrogenation of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase

Published:1974-09-01 Issue:3 Volume:141 Page:729-732
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Adams Paul R.¹,Harrison Roger¹,Inch Thomas D.²²

Affiliation:

1. Biochemistry Group, School of Biological Sciences, University of Bath, Bath BA2 7AY, U.K.

2. Chemical Defence Establishment, Porton, Salisbury, SP4 0JQ, U.K.

Abstract

S-(+)-3,4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-phosphate, was synthesized stereospecifically and shown to be an effective substrate for rabbit muscle glycerol 3-phosphate dehydrogenase (sn-glycerol 3-phosphate–NAD+oxidoreductase, EC 1.1.1.8). Non-isosteric phosphonate analogues of sn-glycerol 3-phosphate showed neither substrate nor inhibitory activity with the enzyme.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/141/3/729/562963/bj1410729.pdf

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